Intergenic Retrotransposons Can Serve Long-Range Functions

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Retrotransposons (which include LINEs, SINEs, and ERVs) are known for the ability of their long-terminal repeats (LTRs) to serve as promoters and enhancers for regulating the expression of genes that are immediately downstream (Conley et al., 2008Dunn et al., 2005). The majority of retrotransposons, however, are located considerable distances from genes (often hundreds of kilobases away) — and this has often been taken as evidence that the majority of these retrotransposons are, in fact, non-functional.

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